Name: Galectin-10 (F1Z5W) Rabbit Monoclonal Antibody
Price: 178.00 USD
Availability: InStock

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IHC

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)
Source/Isotype	Rabbit IgG

Application Key:

IHC-Immunohistochemistry

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Immunohistochemistry (Paraffin)	1:200 - 1:800

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

Galectin-10 (F1Z5W) Rabbit Monoclonal Antibody recognizes endogenous levels of total galectin-10 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human galectin-10 protein.

Background

Galectin-10 is a lectin that is highly expressed in human basophils and eosinophils, where it can be found in the peripheral cytoplasm (1,2). Galectin-10 is not expressed in mice (3). In eosinophilic inflammatory conditions, including asthma and parasitic infections, galectin-10 can crystallize into structures called Charcot-Leyden crystals (CLCs) (2,4). CLCs themselves are associated with eosinophil extracellular trap cell death (EETosis), and they activate the NLRP3 inflammasome, resulting in IL-1β release and a local inflammatory environment (5,6). While CLCs induce an inflammatory response, soluble galectin-10 does not; consequently, CLCs represent a therapeutic target in eosinophilic asthma and allergy (7,8).

Alternate Names

Charcot-Leyden crystal galectin; Charcot-Leyden crystal protein; CLC; Eosinophil lysophospholipase; Gal-10; GAL10; galectin 10; Galectin-10; lectin, galactoside-binding, soluble, 10; LEG10; LGALS10; LGALS10A; LPPL; LPPL_HUMAN; Lysolecithin acylhydrolase; MGC149659

Database Links

UniProt ID: Q05315

Entrez-Gene Id: 1178

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Galectin-10 (F1Z5W) Rabbit Monoclonal Antibody #25218