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  3. FoxP4 (F5S4L) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FoxP4 (F5S4L) Rabbit Monoclonal Antibody #42440

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 85
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:50 - 1:250
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    FoxP4 (F5S4L) Rabbit Monoclonal Antibody recognizes endogenous levels of total FoxP4 protein. This antibody does not cross-react with FoxP1, FoxP2, or FoxP3 proteins.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu230 of human FoxP4 protein.

    Background

    Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5).

    FoxP4 regulates development in heart and lung tissues, and its deletion results in embryonic lethality (5,6). FoxP4 is not required for T cell development, but does play a role in effector T cell cytokine responses in chronic infection (7).

    Alternate Names

    FKHLA; FLJ40908; FLJ44184; fork head-related protein like A; Fork head-related protein-like A; forkhead box P4; Forkhead box protein P4; FOXP4; hFKHLA; winged-helix repressor FOXP4

    Database Links

    UniProt ID: Q8IVH2


    Entrez-Gene Id: 116113


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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