FoxJ1 (F2T8F) Rabbit Monoclonal Antibody #91798

Forkhead box protein J1 (FoxJ1) is a transcription factor required for motile cilia formation. As a member of the forkhead/winged box domain family, FoxJ1 contains a conserved DNA-binding domain that directly binds ciliated gene enhancer regions in an RFX2/3 protein-dependent manner (1-3). FoxJ1 is highly expressed during embryonic development in ciliated epithelial cells of the airway, fallopian tube, testis, and choroid plexus (4-6). Single cell analysis revealed that in fallopian tube epithelial cells, the expression of FOXJ1 and transcription factor PAX8 was inversely correlated between ciliated versus secretory cell populations (7). Exogenous FoxJ1 expression in FOXJ1-/- cells revealed that it functions in late-stage ciliogenesis only in cells that have previously differentiated to a ciliated phenotype (8). In addition to driving the transcription of genes responsible for cilia formation and motility, FoxJ1 is required for proper apical membrane presentation of cilia basal bodies (8,9). Activation of Stat6 by IL-13 mediates FoxJ1 expression in airway epithelia in response to airway injury or chronic disease (10,11). FoxJ1 protein is frequently detected in multiciliated cell subpopulations of invasive ductal carcinomas (12).