FoxC2 (D4D4) Rabbit Monoclonal Antibody #12974

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors defined by the presence of a winged helix DNA-binding domain called a Forkhead box (1). In humans, there are over 40 known Fox protein family members, divided into 19 subfamilies, which have evolved to regulate gene transcription in diverse and highly specialized biological contexts throughout development (2). Mutations that disrupt the expression of Fox gene family members have consequently been implicated in a broad array of human disorders, including immunological dysfunction, infertility, speech/language disorders, and cancer (3,4).

The expression of FoxC2 and several other Fox transcription factors are regulated during adipogenesis, suggesting their involvement in adipocyte differentiation (5). A transgenic mouse model exhibiting over expression of FoxC2 in white adipose tissue (WAT) and brown adipose tissue (BAT) showed a reduction of the intra-abdominal WAT depot (6). The BAT-specific gene Ucp1 is upregulated in the intra-abdominal WAT depot of these transgenic mice, resulting in histological features similar to those seen in BAT. This evidence suggests that FoxC2 can play a protective role against obesity and diet-induced insulin resistance (6).