FHIT Antibody

Inquiry Info. # 4704

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Product Specifications

REACTIVITY
SENSITIVITY	Endogenous
MW (kDa)	16
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

FHIT Antibody detects endogenous levels of total FHIT protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the amino terminus of human FHIT. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The fragile histidine triad (FHIT) tumor suppressor gene is frequently altered in human tumors (1). Adenovirus-mediated FHIT gene transfer has been shown to arrest tumor cell growth and induce apoptosis (2,3), and FHIT-/- knockout mice have a higher incidence of spontaneous tumor formation (4,5). FHIT physically associates with ubiquitin-conjugating enzyme 9 (6), and Src has been reported to phosphorylate Tyr114 of FHIT in vitro and in vivo (7). FHIT is a diadenosine P1,P3-triphosphate hydrolase (8), but a His96Asn mutation, which reduces FHIT enzymatic activity by three-fold, does not reduce FHIT tumor suppressor activity (8,9).

Alternate Names

AP3A hydrolase; AP3Aase; Bis(5'-adenosyl)-triphosphatase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; FHIT; FRA3B; fragile histidine triad diadenosine triphosphatase; fragile histidine triad gene; Fragile histidine triad protein; tumor suppressor protein

Database Links

UniProt ID: P49789

Entrez-Gene Id: 2272

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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FHIT Antibody #4704