FABP6 (F9U9N) Rabbit Monoclonal Antibody #59089

Fatty acid-binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones. They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes and are increasingly being understood to play key roles in disease (2). Fatty acid-binding protein 6 (FABP6), also known as ileal bile acid-binding protein (I-BABP), is highly expressed in the ileum, where it binds bile acid and regulates the ileal bile acid transport system (3,4). FABPs play a role in cancer initiation and progression, and FABP6 has been identified as a potential therapeutic target and prognostic marker for multiple cancers (5-7). In a study of tumor immune infiltration in colorectal cancer (CRC), knockdown of FABP6 promoted the recruitment of CD8⁺ T cells via enhancing the immunogenicity of tumor cells and promoting chemokine secretion (8).