Name: ELMO1 (D4K2E) Rabbit Monoclonal Antibody
Price: 351.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	80
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

ELMO1 (D4K2E) Rabbit Monoclonal Antibody recognizes endogenous levels of total ELMO1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala567 of human ELMO1 protein.

Background

Engulfment and cell motility 1 (ELMO1) is a cell motility and migration protein that interacts with DOCK180 to form an atypical, two-part guanine nucleotide exchange factor (GEF) for the small GTPase Rac (1). The resultant localized Rac activation allows actin nucleation via WAVE family proteins, signaling to integrins, formation of lamellipodia and filopodia, and regulation of processes including phagocytosis and cell migration (2-4). Research studies indicate that DOCK180 and ELMO1 regulate cell migration in lymphocytes (5) and in ovarian cancer cells (6). ELMO1 also promotes Rac1-dependent cell motility through its interaction with the adaptor protein Nck-1 (7), and binds Arhgef16 to promote RhoG/Rac1-dependent engulfment of apoptotic cells by phagocytes (8). Polymorphisms in the corresponding ELMO1 gene may be associated with susceptibility to diabetic neuropathy seen in selected populations of type II diabetic patients (9,10).

Alternate Names

CED-12; ced-12 homolog 1; CED12; ELMO-1; ELMO1; engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; MGC126406; Protein ced-12 homolog

Database Links

UniProt ID: Q92556

Entrez-Gene Id: 9844

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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ELMO1 (D4K2E) Rabbit Monoclonal Antibody #14457