Name: EDIL3/DEL1 (F9D5E) Rabbit Monoclonal Antibody
Price: 161.00 USD
Availability: InStock

Filter:

WB
IF

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	65
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IF-Immunofluorescence

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Simple Western™	1:10 - 1:50
Immunofluorescence (Immunocytochemistry)	1:50 - 1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

EDIL3/DEL1 (F9D5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total EDIL3/DEL1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human EDIL3/DEL1 protein.

Background

EGF-like repeats and discoidin I-like domain 3 (EDIL3), also known as developmental endothelial locus-1 (DEL1), is a secreted protein that can interact with integrins (1,2). EDIL3/DEL1 is an anti-inflammatory protein that can be produced by endothelial cells, macrophages, neurons, and osteoclasts (3). EDIL3/DEL1, produced by endothelial cells, counteracts inflammation by limiting leukocyte recruitment. It binds to β2 integrins expressed on neutrophils, preventing them from interacting with ICAM-1 and disrupting neutrophil migration along the endothelium (3,4). EDIL3/DEL1 can also promote resolution by promoting macrophage clearance of apoptotic neutrophils, or efferocytosis, by acting as a bridge, binding macrophage αvβ3 integrin and apoptotic neutrophil phosphatidylserine (1,3). EDIL3/DEL1 deficiency is associated with several inflammatory conditions, including ankylosing spondylitis and multiple sclerosis (5,6). In cancer, however, EDIL3/DEL1 expression is often upregulated, promoting angiogenesis and epithelial-mesenchymal transition, making it a potential therapeutic target (7-9).

Alternate Names

DEL1; developmental endothelial locus-1; Developmentally-regulated endothelial cell locus 1 protein; EDIL3; EGF like repeats and discoidin domains 3; EGF-like repeat and discoidin I-like domain-containing protein 3; EGF-like repeats and discoidin I-like domains 3; Integrin-binding protein DEL1; MGC26287

Database Links

UniProt ID: O43854

Entrez-Gene Id: 10085

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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EDIL3/DEL1 (F9D5E) Rabbit Monoclonal Antibody #90273