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  3. Dvl3 Antibody

Dvl3 Antibody #3218

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R Hm Mk Mi B
    SENSITIVITY Endogenous
    MW (kDa) 88 to 93
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Hm-Hamster 
    • Mk-Monkey 
    • Mi-Mink 
    • B-Bovine 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Dvl3 Antibody detects endogenous levels of total Dvl3 protein. This antibody does not cross-react with Dvl2.

    Species Reactivity:

    Human, Mouse, Rat, Hamster, Monkey, Mink, Bovine

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the carboxy terminus of human Dvl3. The antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).

    Alternate Names

    dishevelled 3 (homologous to Drosophila dsh); dishevelled segment polarity protein 3; Dishevelled-3; dishevelled, dsh homolog 3; dishevelled, dsh homolog 3 (Drosophila); DRS3; DSH homolog 3; DVL3; KIAA0208; Segment polarity protein dishevelled homolog DVL-3

    Database Links

    UniProt ID: Q92997


    Entrez-Gene Id: 1857


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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