Dexras1 Antibody #4229
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 30 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Dexras1 Antibody detects endogenous levels of total Dexras1 protein. The antibody also cross-reacts with a 60 kDa protein of unknown origin.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Dexras1 protein. Antibodies were purified by protein A and peptide affinity chromatography.
Background
Dexras1 (Ras dexamethasone induced 1) belongs to the Ras superfamily of GTPases and was initially identified as a dexamethasone inducible gene (1,2). Dexras1 reportedly regulates several distinct signal transduction pathways, including MAPK signaling, NMDA receptor-nitric oxide-mediated signaling, and pathways involving adenylyl cyclases (3-5). Dexras1 can directly modulate FE65-APP-mediated transcription and regulate the photic sensitivity of the mammalian circadian clock (6,7).
- Kemppainen, R.J. and Behrend, E.N. (1998) J Biol Chem 273, 3129-31.
- Tu, Y. and Wu, C. (1999) Biochim Biophys Acta 1489, 452-6.
- Fang, M. et al. (2000) Neuron 28, 183-93.
- Graham, T.E. et al. (2004) Biochem Biophys Res Commun 316, 307-12.
- Nguyen, C.H. and Watts, V.J. (2005) Biochem Biophys Res Commun 332, 913-20.
- Cheng, H.Y. et al. (2006) J Neurosci 26, 12984-95.
- Lau, K.F. et al. (2008) J Biol Chem 283, 34728-37.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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