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  3. CXCR4 (E3Q4B) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CXCR4 (E3Q4B) Rabbit Monoclonal Antibody #64837

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 42-50
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    CXCR4 (E3Q4B) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCR4 protein. This antibody may also detect N-terminal cleavage products resulting from elastase cleavage.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human CXCR4 protein. Epitope mapping determined this antibody recognizes a region surrounding Gly273.

    Background

    CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied as a potential therapeutic target in the context of autoimmune diseases (3), as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4).

    Alternate Names

    C-X-C chemokine receptor type 4; C-X-C motif chemokine receptor 4; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; CXC-R4; CXCR-4; CXCR4; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIM; WHIMS

    Database Links

    UniProt ID: P61073


    Entrez-Gene Id: 7852


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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