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  3. CLEC5A (F4S6B) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CLEC5A (F4S6B) Rabbit Monoclonal Antibody #30540

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  • WB

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 30-45, 22
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    CLEC5A (F4S6B) Rabbit Monoclonal Antibody recognizes endogenous levels of total CLEC5A protein. This antibody detects an 80 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CLEC5A protein.

    Background

    C-Type lectin domain family 5 member A (CLEC5A), also known as myeloid DAP12-associating Lectin-1 (MDL-1), is a type II transmembrane receptor predominantly found on myeloid cells, including macrophages, neutrophils, and dendritic cells (1). CLEC5A serves as an immune sensor for various pathogens, recognizing and binding to specific glycan structures present on the surfaces of viruses and bacteria, such as dengue virus (DENV) and Japanese encephalitis virus (JEV) (2-4). Upon pathogen binding, CLEC5A associates with the tyrosine-phosphorylated DAP12, leading to the release of pro-inflammatory cytokines (2-4). CLEC5A has also emerged as a potential biomarker for M2-like macrophages in the tumor microenvironment (5,6).

    Alternate Names

    C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain containing 5A; C-type lectin domain family 5 member A; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; C-type lectin, superfamily member 5; CLC5A; CLEC5A; CLECSF5; MDL-1; MDL1; MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1

    Database Links

    UniProt ID: Q9NY25


    Entrez-Gene Id: 23601


    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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