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  3. Claudin-4 (F8I6W) Rabbit Monoclonal Antibody
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Claudin-4 (F8I6W) Rabbit Monoclonal Antibody #94478

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 19
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    Claudin-4 (F8I6W) Rabbit Monoclonal Antibody recognizes endogenous levels of total claudin-4 protein. A band of unknown origin is detected at 90 kDa in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys191 of human claudin-4 protein.

    Background

    Tight junctions, or zonula occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Tight junctions are composed of claudin and occludin proteins, which join the junctions to the cytoskeleton (1,2). The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer (2,3). Claudin-1 is expressed primarily in keratinocytes (4) and normal mammary epithelial cells, but is absent or reduced in breast carcinomas and breast cancer cell lines (5,6).

    Claudin-4 (CLDN4) is overexpressed in many epithelial malignancies and correlates with cancer progression (reviewed in 7). Decreased expression of claudin-4 is associated with epithelial-mesenchymal transition (EMT).

    Alternate Names

    claudin 4; Claudin-4; claudin4; CLD4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPE-R; CPE-receptor; CPER; CPETR; CPETR1; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein

    Database Links

    UniProt ID: O14493


    Entrez-Gene Id: 1364


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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