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  3. CHMP2A (F4T1J) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CHMP2A (F4T1J) Rabbit Monoclonal Antibody #24666

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    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 28, 31
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100
    Immunofluorescence (Immunocytochemistry) 1:200 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    CHMP2A (F4T1J) Rabbit Monoclonal Antibody recognizes endogenous levels of total CHMP2A protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CHMP2A protein.

    Background

    CHMP2A is a component of ESCRT-III (endosomal sorting complex required for transport-III) (1,2). The ESCRT system is comprised of multiple protein complexes denoted as ESCRT-0, -I, -II, and -III, and VPS4 ATPase that are recruited to various cellular membranes and function fission reactions (3,4). Yeast contains four core ESCRT-III subunits: Vps20, Snf7, Vps24, and Vps2. Humans share these subunits and additionally have four Snf7 paralogs (CHMP4A-D) and two Vps2 paralogs (CHMP2A and B). The ESCRT-III complex comprising CHMP2A is involved in various membrane events, including multivesicular bodies, viral budding, cytokinesis, nuclear membrane reformation, and phagophore closure during autophagy and mitophagy (5-9).

    Alternate Names

    BC-2; BC2; Charged multivesicular body protein 2a; CHM2A; CHMP2; CHMP2A; chromatin modifying protein 2A; Chromatin-modifying protein 2a; hVps2-1; putative breast adenocarcinoma marker (32kD); Putative breast adenocarcinoma marker BC-2; Vacuolar protein sorting-associated protein 2-1; VPS2; VPS2 homolog A; Vps2-1; VPS2A

    Database Links

    UniProt ID: O43633


    Entrez-Gene Id: 27243


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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