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  3. CEACAM6 (E7S7Y) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CEACAM6 (E7S7Y) Rabbit Monoclonal Antibody #85102

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  • WB
  • IHC

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 50-200
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:1600 - 1:6400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #51309.

    实验步骤

    Specificity / Sensitivity

    CEACAM6 (E7S7Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total CEACAM6 protein. This antibody does not cross-react with CEACAM1, 5, or 8 proteins.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys246 of human CEACAM6 protein.

    Background

    Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA-related cell adhesion molecule (CEACAM) family (1). CEACAMs bind to themselves and other family members to carry out numerous cellular functions, including proliferation, signaling, differentiation, tumor suppression, and survival (2). CEACAM6 is a single-chain, glycosylphosphatidylinositol (GPI)-anchored, highly glycosylated protein that is normally expressed on epithelial cells and granulocytes (3,4). CEACAM6 mediates homophilic and heterophilic cell adhesion with other CEA-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (3-6). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (7), and plays a role in neutrophil adhesion to cytokine-activated endothelial cells (4). High levels of CEACAM6 expression are also observed in several different cancers (8-10). In cancer, CEACAM6 promotes tumor progression, migration, invasion, and metastasis, and therefore is considered a target for therapeutic intervention (11-13).

    Alternate Names

    carcinoembryonic antigen related cell adhesion molecule 6; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66c; CEA cell adhesion molecule 6; CEACAM6; CEAL; CEAM6; Cluster of Differentiation 66c; NCA; Non-specific crossreacting antigen; Normal cross-reacting antigen

    Database Links

    UniProt ID: P40199


    Entrez-Gene Id: 4680


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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