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  3. CD103/ITGAE (F2C7B) Rabbit Monoclonal Antibody
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CD103/ITGAE (F2C7B) Rabbit Monoclonal Antibody #67499

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    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous (IHC-P, IF-F), Transfected (W)
    MW (kDa) 130
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:200 - 1:800
    Immunofluorescence (Frozen) 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    CD103/ITGAE (F2C7B) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD103/ITGAE protein. Nonspecific staining was observed in mouse kidney tubules, testis Leydig cells, and forestomach epithelium by immunohistochemistry.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu152 of mouse CD103/ITGAE protein.

    Background

    Cluster of differentiation molecule 103 (CD103)/Integrin, alpha E (ITGAE) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD103/ITGAE is expressed by subsets of CD4+ and CD8+ T cells, dendritic cells, and mast cells in mucosal tissues (1,2). The heterodimer composed of CD103/ITGAE and integrin beta 7 interacts with E-cadherin, a cellular adhesion molecule found on epithelial cells. The CD103/ITGAE and integrin beta 7 complex plays a role in thymocyte proliferation, intestinal T cell homing, and the antitumor immune response (3-5). Studies have shown that the presence of CD103/ITGAE(+) immune cells can be used as markers for a favorable prognosis in different epithelial cancers (6,7).

    Alternate Names

    A530055J10; alph; alpha-E1; alpha-M290; aM290; CD103; integrin alpha E, epithelial-associated; Integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; ITAE; Itgae; MGC183601; OTTMUSP00000006421; OTTMUSP00000006422

    Database Links

    UniProt ID: Q60677


    Entrez-Gene Id: 16407


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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