CD101/IgSF2 (F2L8J) Rabbit Monoclonal Antibody #46283

Cluster of differentiation molecule 101 (CD101), also known as immunoglobulin superfamily member 2 (IgSF2) and cell surface glycoprotein V7, is a type I transmembrane glycoprotein with an extracellular region composed of seven IgV-like domains (1,2). CD101 is expressed on T cells, dendritic cells (DCs), and monocytes (3). On T cells, CD101 expression is induced following T cell receptor (TCR) stimulation and plays an immunoregulatory role, inhibiting proliferation and IL-2 production by blocking Ca2⁺ flux and nuclear factor of activated T cells (NFAT) nuclear translocation (4). Regulatory T cells (Tregs) can express high levels of CD101 and are more suppressive than CD101^- Tregs in in vitro suppression assays (5). CD101 is highly expressed on activated mucosal tissue-resident memory T cells and may play a role in balancing anti-inflammatory Tregs and pro-inflammatory Th17 cells in mucosal tissue (6). In CD8⁺ T cells, CD101 and TIM-3 expression defines a terminally differentiated state of exhaustion and dysfunction arising from chronic viral infection (7). In cutaneous DCs, triggering CD101 may lead to IL-10 production and the suppression of T cell proliferation (8). CD101 has been identified as a prognostic marker in glioma correlating with unfavorable overall survival and was found to be expressed at high levels on M2-like tumor-associated macrophages (TAMs) (9).