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  3. CCL20 (E6J9K) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CCL20 (E6J9K) Rabbit Monoclonal Antibody #76924

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 9
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    CCL20 (E6J9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total CCL20 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human CCL20 protein.

    Background

    Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a chemokine that mediates leukocyte migration during inflammation and homeostasis (1-3). CCL20 is expressed by T helper (Th) 17 cells (Th17), B cells, natural killer cells, neutrophils, dendritic cells (DC), macrophages, and endothelial cells (4-6). Its receptor, C-C chemokine receptor 6 (CCR6), is expressed by immune cells, such as regulatory CD4+ T cells (Tregs), Th17 cells, CD8+ T cells, and B cells, and drives their migration into CCL20 rich tissues (7). In induced Tregs, CCL20 ligation with its receptor suppresses Treg function via signaling through the AKT/mTOR/STAT3 axis (8). The CCR6-CCL20 axis is being investigated as a therapeutic target for its role in autoimmune disease, viral infection, and cancer progression (7,9).

    Alternate Names

    beta chemokine exodus-1; Beta-chemokine exodus-1; C-C motif chemokine 20; C-C motif chemokine ligand 20; CC chemokine LARC; CCL20; CCL20(1-64); CCL20(1-67); CCL20(2-70); chemokine (C-C motif) ligand 20; CKb4; Exodus; LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; MIP-3a; MIP3A; SCYA20; small inducible cytokine subfamily A (Cys-Cys), member 20; Small-inducible cytokine A20; ST38

    Database Links

    UniProt ID: P78556


    Entrez-Gene Id: 6364


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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