Cathepsin A (F8X9E) Rabbit Monoclonal Antibody #67452

Cathepsin A, also known as lysosomal protective protein for beta-galactosidase (PPGB), functions as both a serine protease and a critical enzyme for stabilizing β-galactosidase and neuraminidase (1,2). Similar to other cathepsin family members, cathepsin A is synthesized as an inactive 54 kDa precursor, then cleaved into catalytically active large (32 kDa) and small (20 kDa) subunits that form a disulfide-linked heterodimer after excision of a linker peptide (1-3). Cathepsin A degradation targets include endothelin (4), LAMP2 (5), and angiotensin I (6). CTSA gene mutations result in protein misfolding and lysosomal galactosialidosis, as neuraminidase and β-galactosidase activity depend on direct association with cathepsin A (7,8). Cathepsin A overexpression in heart causes excess degradation of superoxide dismutase (SOD), increasing oxidative stress, inflammation, and remodeling of the extracellular matrix (ECM) (9). High expression of cathepsin A has been reported and associated with metastasis in melanocytic tumors, colorectal cancer, hepatocellular carcinoma, and lung adenocarcinoma (10-13).