ATP5B (E8A5A) Rabbit Monoclonal Antibody #85001

ATP5B (ATP5F1B) is the catalytic β subunit of the F₁ portion of the F₁F₀ ATP synthase, which is responsible for the majority of ATP synthesis in oxidative phosphorylation (1). ATP5B is present in the inner membrane of mitochondria in all types of cells, where it functions as an ATP provider and plays an important role in maintaining intracellular energy homeostasis. A high level of ATP5B is associated with cancer proliferation, metastasis, and drug resistance (2-4). An increased level of ATP5B plays an important protective role in decreasing renal fibrosis (5). Cell surface expression of ATP5B has been found in various cell types, including tumor, endothelial, and neuronal cells (6), where it is involved in multiple biological processes depending on the cell types. These include promoting viral entry (7), serving as a ligand for tumor-T cell recognition (8), generating extracellular ATP, contributing to intracellular PH homeostasis (9), and facilitating tumor metastasis (10). Inhibition of ATP5B has been proposed as a potential treatment for aggressive cancer (11,12).