Annexin A6 Antibody #29015

Annexin A6 (ANXA6) belongs to the highly conserved annexin family of proteins characterized by their calcium (Ca²⁺)-dependent binding to phospholipids (1-3). The protein is highly expressed in most tissues and is predominantly located at the plasma membrane and the endosomal compartment, where it regulates cell migration and endosome trafficking by organizing membrane domains, interacting with signaling complexes, and forming transient membrane-actin interactions upon Ca²⁺ stimulation (3). It also mediates intracellular cholesterol homeostasis (3,4). Annexin A6 is frequently upregulated in extracellular vesicles (EVs) of the tumor microenvironment after chemotherapy or tyrosine kinase inhibitor treatment. These EVs have been shown to promote resistance and metastasis in multiple cancer types, such as lung cancer, breast cancer, and pancreatic duct adenocarcinoma (5-7). Annexin A6, in these EVs, enhances the stability of membrane-associated RTKs, such as EGFR, and promotes cancer cell motility, stemness, and autophagy (2,7-9).