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  3. Human CTGF Recombinant Protein

Human CTGF Recombinant Protein #58518

    Product Information

    Product Usage Information

    Working concentration of recombinant hCTGF generally ranges from 10 ng/mL-4 μg/ml.

    Storage

    Stable in lyophilized state at -20°C for 24 months after receipt.

    It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

    Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

    Product Description

    MW (kDa) 11.2
    Purity A greater than or equal to 90% purity was determined by SDS-PAGE.
    Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hCTGF.
    Activity The bioactivity of recombinant hCTGF was determined in a HUVEC cell proliferation assay. The ED50 of each lot is less than or equal to 2,000 ng/mL.

    Source / Purification

    Recombinant human CTGF was expressed in E. coli and is supplied in a lyophilized form.

    Background

    Connective tissue growth factor (CTGF, CCN2) belongs to the CCN (CYR61, CTGF, NOV) family of secreted extracellular matrix (ECM) proteins (1). Members of this family contain four conserved cysteine-rich domains, and interact in the ECM with a diverse array of cell surface receptors, including integrins and heparin-sulfate proteoglycans (2). These interactions regulate a multitude of cellular and tissue functions, including adhesion, proliferation, migration, differentiation, senescence, angiogenesis, inflammation, and wound repair (1,3-5). The CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9).

    Database Links

    UniProt ID: P29279


    Entrez-Gene Id: 1490


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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