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HTScan® PDK1 Kinase Assay Kit

HTScan^® PDK1 Kinase Assay Kit #7577

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Product Information

Product Description

The kit provides a means of performing kinase activity assays with recombinant human PDK1 kinase. It includes active PDK1 kinase (supplied as a GST fusion protein), a biotinylated peptide substrate and a phospho-serine/threonine antibody for detection of the phosphorylated form of the substrate peptide.

Molecular Formula

Biotin-peptide: 2,205 Daltons. PDK1 Kinase: 67 kDa.

Background

Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways (1,2) including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK (3). Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.

Alternate Names

3-phosphoinositide dependent protein kinase-1; enzyme; hPDK1; kinase; kinase PDK1; mPDK1; PDPK1; PkB kinase; Protein kinase B kinase

Database Links

UniProt ID: O15530

Entrez-Gene Id: 5170

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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HTScan® PDK1 Kinase Assay Kit #7577