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  3. Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor® 750 Conjugate)
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Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor® 750 Conjugate) #91322

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    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • IHC-Immunohistochemistry 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Description

    This Cell Signaling Technology® antibody is conjugated to Alexa Fluor® 750 fluorescent dye under optimal conditions. This antibody conjugate is expected to exhibit the same species cross-reactivity as the unconjugated Pan-Keratin (C11) Mouse mAb #4545.

    Fluorescent Properties

    • ← Excitation: 749 nm ← Emission: 775 nm

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:50 - 1:200
    Flow Cytometry (Fixed/Permeabilized) 1:200

    Storage

    Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

    实验步骤

    Specificity / Sensitivity

    Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor® 750 Conjugate) detects endogenous levels of total keratin 4, 5, 6, 8, 10, 13, and 18. This antibody conjugate does not cross-react with other keratins.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody (isotype: IgG1) is produced by immunizing a BALB/c mouse with a cytoskeleton preparation from A-431 cells.

    Background

    KHSRP, also known as KSRP, is a KH domain-containing AU-rich element (ARE) binding protein (1). It recruits degradation machinery and activates mRNA turnover (2). This protein was previously shown to function as a regulator for splicing (3). KHSRP associates with both the Drosha and Dicer multiprotein complexes (4), and controls the biogenesis of some microRNAs by binding to the terminal loops of these microRNA precursors (3). KHSRP is found in neural and non-neural cell types in both the nucleus and the cytoplasm (4).

    Alternate Names

    56 cytoskeletal type II keratin; 58 kDa cytokeratin; BCIE; BIE; CARD2; Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-10; CK-13; CK-18; CK-4; CK-5; CK-6A; CK-6B; CK-6C; CK-6D; CK-6E; CK-8; CK10; CK13; CK4; CK5; CK6A; CK6B; CK6C; CK6D; CK8; CYK18; CYK4; CYK8; cytokeratin 10; cytokeratin 13; cytokeratin 18; cytokeratin 4; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; cytokeratin 8; Cytokeratin-10; Cytokeratin-13; Cytokeratin-18; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; Cytokeratin-8; DDD; DDD1; EBS2; EHK; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; FLJ31692; K10; K13; K18; K1C10; K1C13; K1C18; K2C4; K2C5; K2C6A; K2C6B; K2C6C; K2C8; K4; K5; K6A; K6B; K6C; K6D; K6D keratin; K6E; K8; keratin 10; keratin 10, type I; keratin 13; keratin 13, type I; keratin 18; keratin 18, type I; keratin 4; keratin 4, type II; keratin 5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin 6; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 6B, type II; keratin 6C; keratin 6C, type II; keratin 6E; keratin 8; keratin 8, type II; Keratin K6h; Keratin-10; Keratin-13; Keratin-18; Keratin-4; Keratin-5; Keratin-6A; Keratin-6B; Keratin-6C; Keratin-8; keratin-like 1 (a type II keratin sequence); keratin, epidermal type II, K6A; keratin, epidermal type II, K6C; keratin, epidermal, type II, K6B; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 18; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; keratin, type II cytoskeletal 6D; Keratin, type II cytoskeletal 8; KO; KPP; KRT10; KRT13; KRT18; KRT4; KRT5; KRT5A; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; KRT8; KRTL1; MGC102925; MGC161462; MGC163455; MGC163457; MGC3781; PC2; PC3; PC4; PPKNEFD; type II keratin isoform K6c; Type-II keratin Kb10; Type-II keratin Kb12; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb8; WSN1; WSN2

    Database Links

    UniProt ID: P48668 , P13645 , P04259 , P05787 , P13646 , P02538 , P05783 , P13647 , P19013


    Entrez-Gene Id: 286887 , 3858 , 3854 , 3856 , 3860 , 3853 , 3875 , 3852 , 3851


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    Alexa Fluor is a registered trademark of Life Technologies Corporation.
    This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
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