USP18 Antibodies

Target Information

Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins. Belongs to the peptidase C19 family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

1110058H21Rik; 43 kDa ISG15-specific protease; AW047653; hUBP43; ISG15-specific-processing protease; ISG43; PTORCH2; ubiquitin specific peptidase 18; ubiquitin specific protease 15; ubiquitin specific protease 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; ubl thiolesterase 18; Ubp15; UBP18; UBP4; UBP43; Ubp43; USP18; Usp18