TRIAD3 Antibodies

Target Information

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

2810055G22Rik; AI647468; AU019462; C86502; CAHH; E3 ubiquitin ligase; E3 ubiquitin-protein ligase RNF216; F830018F18Rik; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; RN216; RNF216; Rnf216; Triad domain-containing protein 3; TRIAD3; Triad3; U7I1; Ubce7i; UBCE7IP1; Ubce7ip1; UbcM4-interacting protein 83; ubiquitin conjugating enzyme 7 interacting protein 1; Ubiquitin-conjugating enzyme 7-interacting protein 1; UIP; Uip83; ZIN; Zin; Zinc finger protein inhibiting NF-kappa-B