TIMP1 Antibodies

Target Information

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Belongs to the protease inhibitor I35 (TIMP) family. Detected in rheumatoid synovial fluid (at protein level). Note: This description may include information from UniProtKB.

Alternate Names

CLGI; Clgi; Collagenase inhibitor; Collagenase inhibitor 16C8 fibroblast; EPA; epididymis secretory sperm binding protein; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; Metalloproteinase inhibitor 1; MGC7143; OTTMUSP00000018691; OTTMUSP00000018692; TIMP; Timp; TIMP metallopeptidase inhibitor 1; TIMP-1; TIMP1; Timp1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase-1; tissue inhibitor of metalloproteinases; Tissue inhibitor of metalloproteinases 1; TPA-induced protein; TPA-S1