RANBP3 Antibodies
Target Information
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. Widely expressed with high levels in testis and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Alternate Names
DKFZp586I1520; epididymis secretory sperm binding protein; RAN binding protein 3; Ran-binding protein 3; RAN-binding protein-3; RANB3; RANBP3RANBP3 Antibody Products
2 ProductsWhy CST
Cell Signaling Technology is trusted by the global scientific research community. Our highly cited antibodies offer unrivaled specificity and reproducibility. Learn more about why researchers choose CST:
Contact
Don’t see an antibody for your specific needs? Browse more products, learn more about our services or get in touch with us: