RAD21 Antibodies

Target Information

Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression. Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development. 64-kDa C-terminal product: May promote apoptosis. Belongs to the rad21 family. Expressed in the gut (at protein level). Note: This description may include information from UniProtKB.

Alternate Names

64-kDa C-terminal product; 64-kDa carboxy-terminal product; 65-kDa carboxy-terminal product; CDLS4; Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; hHR21; HR21; HRAD21; KIAA0078; kleisin; MCD1; MGS; Nuclear matrix protein 1; NXP-1; NXP1; protein involved in DNA double-strand break repair; RAD21; RAD21 cohesin complex component; RAD21 homolog; RAD21 homolog (S. pombe); SCC1; SCC1 homolog; sister chromatid cohesion 1