QKI Antibodies

Target Information

RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

DKFZp586I0923; HKQ; homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; HqkI; KH domain-containing RNA-binding protein QKI; Protein quaking; QK; QK1; QK3; QKI; QKI, KH domain containing RNA binding; QKI/LOC100132735 fusion; quaking homolog, KH domain RNA binding; quaking homolog, KH domain RNA binding (mouse); RNA binding protein HQK