PRF1 Antibodies

Target Information

Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.

Alternate Names

Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; Lymphocyte pore-forming protein; MGC65093; P1; PERF; perforin; perforin 1; perforin 1 (pore forming protein); Perforin-1; Pfn; PFN1; PFP; Pfp; pore forming protein; Prf; Prf-1; PRF1; Prf1