OMA1 Antibodies

Target Information

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase M48 family. Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

2010001O09Rik; DAB1; FLJ33782; Metalloendopeptidase OMA1, mitochondrial; metalloprotease related protein 1; Metalloprotease-related protein 1; MPRP-1; MPRP1; OMA1; OMA1 homolog, zinc metallopeptidase; OMA1 homolog, zinc metallopeptidase (S. cerevisiae); OMA1 zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; overlapping activity with M-AAA protease; Overlapping with the m-AAA protease 1 homolog; peptidase; YKR087C; zinc metallopeptidase OMA1; ZMPOMA1