Oct7 Antibodies

Target Information

Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. Belongs to the POU transcription factor family. Class-3 subfamily. Expressed specifically in the neuroectodermal cell lineage. 3 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; BRN2; N-Oct3; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; OCT7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; OTF7; PO3F2; POU class 3 homeobox 2; POU domain, class 3, transcription factor 2; POU3F2; POUF3