NDRG1 Antibodies

Target Information

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. Belongs to the NDRG family. Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CAP; CAP43; CMT4D; Differentiation-related gene 1 protein; DRG; DRG-1; DRG1; GC4; HMSNL; N-myc downstream regulated 1; N-myc downstream regulated gene 1; N-myc downstream regulated-like; N-myc downstream-regulated gene 1 protein; NDR1; Ndr1; NDRG1; Ndrg1; Ndrl; Nickel-specific induction protein Cap43; NMSL; PRO; Protein Ndr1; Protein NDRG1; protein regulated by oxygen-1; PROXY1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; TARG1; TDD5; Tdd5; tunicamycin-responsive protein