MX1 Antibodies

Target Information

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

IFI-78K; IFI78; interferon inducible protein p78; Interferon-induced GTP-binding protein Mx1; Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced protein p78; interferon-inducible protein p78; Interferon-regulated resistance GTP-binding protein MxA; lncMX1-215; MX; MX dynamin like GTPase 1; MX1; MxA; Myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse); Myxovirus resistance protein 1