ITGB4 Antibodies
Target Information
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Belongs to the integrin beta chain family. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Alternate Names
CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin subunit beta 4; integrin, beta 4; ITB4; ITGB4ITGB4 Antibody Products
3 Products- 26390WBIHCFHRecombinant Monoclonal
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