IFIT2 Antibodies

Target Information

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. Belongs to the IFIT family. Note: This description may include information from UniProtKB.

Alternate Names

CIG-42; cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; IFIT2; interferon induced protein with tetratricopeptide repeats 2; Interferon-induced 54 kDa protein; interferon-induced protein 54; Interferon-induced protein with tetratricopeptide repeats 2; Interferon, alpha-inducible protein (MW 54kD); ISG-54 K; ISG-54K; ISG54; P54