HIRA Antibodies

Target Information

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Belongs to the WD repeat HIR1 family. Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

DGCR1; DiGeorge critical region gene 1; HIR; HIR histone cell cycle regulation defective homolog A; HIR histone cell cycle regulation defective homolog A (S. cerevisiae); HIRA; histone cell cycle regulator; histone regulator A; Protein HIRA; TUP1; TUP1-like enhancer of split protein 1; TUPLE1