HIF2A Antibodies

Target Information

Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. Note: This description may include information from UniProtKB.

Alternate Names

Basic-helix-loop-helix-PAS protein MOP2; bHLHe7; BHLHE73; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; EPAS1; Epas1; HIF; Hif like protein; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2; HIF-2-alpha; HIF-2alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2-alpha; HIF2A; Hif2a; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2