GZMB Antibodies

Target Information

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. Belongs to the peptidase S1 family. Granzyme subfamily. Note: This description may include information from UniProtKB.

Alternate Names

AI553453; C11; Cathepsin G-like 1; CCP; CCP-1/C1; CCP-1/C11; CCP1; CCPI; CGL-1; CGL1; CSP-B; CSPB; Ctl; Ctla; CTLA-1; CTLA1; Ctla1; CTSGL1; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T-lymphocyte proteinase 2; fragmentin 2; Fragmentin-2; GRAB; Granzyme B; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme B(G,H); Granzyme-2; GRB; GZB; GZMB; Gzmb; HLP; Human lymphocyte protein; Lymphocyte protease; SECT; T-cell serine protease 1-3E