CR1 Antibodies

Target Information

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. (Microbial infection) Acts as a receptor for Epstein-Barr virus. Belongs to the receptors of complement activation (RCA) family. Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. Note: This description may include information from UniProtKB.

Alternate Names

C3-binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CD35 antigen; complement C3b/C4b receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 (Knops blood group); complement component receptor 1; complement receptor 1; Complement receptor type 1; CR1; KN; Knops blood group antigen