CD19 Antibodies
Target Information
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Alternate Names
AW495831; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; B4; CD19; Cd19; CD19 antigen; CD19 molecule; CVID3; Differentiation antigen CD19; MGC12802; T-cell surface antigen Leu-12CD19 Antibody Products
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- 82092CD19 (Intracellular Domain) (D4V4B) Rabbit Monoclonal Antibody (SignalFlex™ mFluor™ UV375 Conjugate)H, M, MkRecombinant Monoclonal
- 98124H, M, MkRecombinant Monoclonal
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