CCND1 Antibodies

Target Information

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Belongs to the cyclin family. Cyclin D subfamily. Note: This description may include information from UniProtKB.

Alternate Names

AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; bcl-; BCL-1; bcl-1; BCL-1 oncogene; BCL1; CCND1; Ccnd1; cD1; CycD1; cyclin D1; Cyl-; Cyl-1; D11S287E; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; OTTMUSP00000031858; PRAD1; PRAD1 oncogene; U21B31