TEAD4 Antibodies

Target Information

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

EFTR-2; hRTEF-1B; MGC9014; related transcription enhancer factor 1B; RTEF1; TCF13L1; TEA domain family member 4; TEA domain transcription factor 4; TEAD-4; TEAD4; TEF-3; TEF3; TEFR-1; Transcription factor 13-like 1; Transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3; Transcriptional enhancer factor TEF-3