SIGMAR1 Antibodies

Target Information

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112. Belongs to the ERG2 family. Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

aging-associated gene 8 protein; ALS16; DSMA2; FLJ25585; hSigmaR1; MGC3851; opioid receptor, sigma 1; OPRS1; OTTHUMP00000000515; OTTHUMP00000000516; OTTHUMP00000000517; OTTHUMP00000021286; Q99720; Q99720-2; Q99720-5; SGMR1; SIG-1R; Sigma 1-type opioid receptor; Sigma non-opioid intracellular receptor 1; sigma non-opioid intracellular receptor 1 isoform 1; sigma1 receptor; Sigma1-receptor; Sigma1R; SIGMAR1; SR-BP; SR-BP1; SR31747 binding protein 1; SR31747-binding protein; SRBP; type I sigma receptor