PRDM14 Antibodies
Target Information
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Belongs to the class V-like SAM-binding methyltransferase superfamily. Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). Note: This description may include information from UniProtKB.
Alternate Names
MGC59730; PFM11; PR domain 14; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing 14; PR domain-containing protein 14; PR-domain zinc finger protein 14; PR/SET domain 14; PRD14; PRDM14PRDM14 Antibody Products
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