PNPLA3 Antibodies

Target Information

Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Acylglycerol O-acyltransferase; Acylglycerol transacylase; Adiponutrin; Adpn; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; Lysophosphatidic acid acyltransferase; patatin-like phospholipase domain containing 3; Patatin-like phospholipase domain-containing protein 3; PLPL3; Pnpla3