HSPC152 Antibodies

Target Information

Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Belongs to the TRM112 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

HSPC152; HSPC170; HSPC170 protein; hTrm112; Multifunctional methyltransferase subunit TRM112-like protein; TR112; TRM112; TRM112-like protein; TRMT11-2; TRMT112; tRNA methyltransferase 11-2 homolog; tRNA methyltransferase 11-2 homolog (S. cerevisiae); tRNA methyltransferase 112 homolog; tRNA methyltransferase subunit 11-2