FBPase Antibodies
Target Information
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Homotetramer. Belongs to the FBPase class 1 family. Expressed in pancreatic islets. Up-regulated in pancreatic islets of individuals with type 2 diabetes. Note: This description may include information from UniProtKB.
Alternate Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; F16P1; FBP; FBP1; FBPase; FBPase 1; Fructose-1,6-bisphosphatase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; liver FBPaseFBPase Antibody Products
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