CASK Antibodies

Target Information

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Belongs to the MAGUK family. Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CAGH39; calcium/calmodulin dependent serine protein kinase; calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK; CASK; CMG; CSKP; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; MRXSNA; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8